* German business climate index increases, survey shows
* London's FTSE 100 leads losses
* Britain's Inmarsat gains on $3.4 bln buyout offer (Updates to closing)By Susan MathewMarch 25 (Reuters) - Europe suffered a fourth day of lossesas persistent worries about the pace of global growth and Brexituncertainty took their toll on shares in the region.The pan-European STOXX 600 index closed 0.45percent lower and is now nearly 3 percent lower than thesix-month peak reached on March 19.European stocks pulled back from an initial 0.8 percent fallafter an unexpected rise in German business sentiment that easedfears of a recession in the European Union's largest economy.London's FTSE 100 led losses with a 0.42 percentfall, while the more domestically-exposed midcap FTSE 250 lost more than 1 percent to hit a six-week low, draggeddown by uncertainty over Britain's EU exit. Germany , Paris and Madrid fellabout 0.2 percent, while Milan lost 0.1 percent,although nearly all major indices were trading below 30-dayaverage volumes.European stocks last week recorded their steepest drop forthe year as weak manufacturing data from Europe and the UnitedStates exacerbated fears of a global slowdown. "Its a lingering fear of the state of the European economy,"said David Madden, an analyst at CMC Markets.Among the biggest fallers on the pan-region index was Bayer , which was down 2.9 percent after the Germanpharmaceuticals group and Johnson & Johnson agreed tosettle thousands of U.S. lawsuits against their blood thinnerXarelto for $775 million. Wood Group was the worst STOXX 600 performer, with a7.6 percent drop, after Jefferies cut its rating on the oilfieldand engineering services provider, citing dividend risks.Meanwhile, British satellite operator Inmarsat's shares rose by 9.6 percent, the biggest gainer on the STOXX 600,after a private equity-led consortium agreed to it for about$3.4 billion in cash.Media shares were the region's biggest losers, down1.4 percent, with the tech sector 0.8 percent lower.
(Reporting by Medha Singh, Agamoni Ghosh and Susan Mathew inBengaluru,Editing by Keith Weir, Ed Osmond and Alexander Smith)